Our recent sequencing analysis of the exomes of 200 cancer-related genes found that mutations in TP53, KRAS, MLL3, SET domain-containing 2 (SETD2), AT rich interactive domain 1A (ARID1A), PIK3CA, and ALK were frequently detected in primary tumors and corresponding patient-derived xenografts of NSCLC [33]. This evidence concerns the gene SETD2 and cancer.