Additionally, Kirsten rat sarcoma viral oncogene homolog (KRAS), cyclin-dependent kinase inhibitor 2A (CDKN2A), mixed-lineage leukemia 3 (MLL3), serine/threonine kinase 11 (STK11), kelch-like ECH-associated protein 1 (KEAP1), and EGFR are the top frequently mutated genes detected in lung adenocarcinomas. This evidence concerns the gene CDKN2A and lung adenocarcinoma.