AIM2 and infection: During infection of its target cells, KSHV must be coming in contact with the host innate immune system’s pattern recognition receptors (PRR), such as Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and absent in melanoma 2 (AIM2)-like receptors (ALRs).