The T2D risk-increasing allele of HNF1B variant rs11651052 (A) was protective against endometrial cancer (OR = 0.82, 95% CI = 0.76 to 0.89, P = 3.7×10–6), while the FG-raising G-allele of ADRA2A variant rs10885122 (OR = 1.32, 95% CI = 1.13 to 1.54, P = 3.6×10–4) was associated with a higher endometrial cancer risk. This evidence concerns the gene ADRA2A and type 2 diabetes mellitus.