LCN2 and digestive system infectious disorder: Furthermore, vascular endothelial B4galnt2 expressing animals (RIII+) exhibited increased Il-6 expression (Z = -1.932, P = 0.0528), but decreased LCN-2 production (S1 Table), suggesting a role for vascular B4galnt2 expression in the host immune response to intestinal infection (Fig 3).