B4GALNT2 and digestive system infectious disorder: In this study, we investigated intestinal infection as a potential driver of selection at B4galnt2 observed in the wild by studying the effect of variant tissue-specific expression of B4galnt2 on host-microbiota interactions and susceptibility to intestinal infection with Salmonella. This revealed strong evidence for the influence of B4galnt2-specific host glycosylation on microbial community composition and a role in pathogen resistance.