Likewise, pitinoic acid B (199) (Figure 33) in LPS-stimulated differentiated THP-1 (human acute monocytic leukemia) cells decreases the level of the pro-inflammatory cytokines TNF-α (tumor necrosis factor alpha) and IL-6 (interleukin 6), which probably accounts for the antiinflammatory effects of 200 [79]. Here, TNF is linked to acute monocytic leukemia.