INSIG1 and neoplasm: In our study, our whole genome array results provided evidence that tumorous DNA acts as a pro-metastatic factor independently from the TLR9 and STING pathways by inducing overexpression of metastasis-associated genes (MACC1, MALAT1,TACSTD2), the tumor marker (CEA), metabolic genes (INSIG1, LIPG) and messenger molecule genes (DAPP, CREB3L2).