Noteworthy is the co-clustering of mutated genes MYC, KRAS, APC and PIK3CA in column-clade C and the co-clustering of RB1 and TP53 in column-clade D. The co-existence of PIK3CA_MUT and KRAS_MUT has been observed in non-small cell lung cancer [35]. The gene discussed is APC; the disease is non-small cell lung carcinoma.