Then, we investigated whether Gpr97 has functions in the regulation of the inflammatory response and the differentiation of Th1/Th2 cells in OVA-induced allergic asthma mice by assessing serum IgE secretion and the expression of the Th1-related cytokine IFN-γ and the Th2-related cytokines IL-4 and IL-6 in the BALF. The gene discussed is IGHE; the disease is allergic asthma.