Seven Rho GTPases (RND1, RND3, RAC3, RHOA, RAC2, RAC1 and RHOC) showed a significantly greater connectivity in grade IV glioma and seven (CHP, RHOD, RHOF, RHOB, RHOQ, RND2, RHOBTB3) showed greater connectivity in grade II glioma. Here, RAC1 is linked to central nervous system cancer.