We also noticed that the transcription of key genes involved in inflammation, proliferation, angiogenesis and extracellular matrix remodelling (including MMP2, HIF1A, IL1B, IL1A, IL1R1, MMP2, VEGFA), processes vital to glioblastoma development, were down-regulated by RND3 knock-down (S6 Fig). The gene discussed is HIF1A; the disease is glioblastoma.