VEGFA and neoplasm: Consistent with the reduced expression of VEGFA mRNA in siRND3 transfected U87 cells, blood vessel density in siRND3 tumours was significantly lower compared to control tumours (Fig 5R; siRND3 oligo B U87 10.6±2.79; control U87 23.8±2.13), suggesting a disrupted angiogenesis process.