TP53 and head and neck squamous cell carcinoma: Interestingly, the rs2279115 A allele may render a better interaction with TP53, leading to a decrease in the BCL2 expression, an up-regulated programmed cell death or reduced longevity of transformed cells, and thus a subsequent decrease in the risk of malignances, such as squamous cell carcinoma of the head and neck (SCCHN)19.