RYR2 and catecholaminergic polymorphic ventricular tachycardia 1: In particular, RYR2 has previously been reported as gene associated with several arrhythmic diseases, including LQTS [38], catecholaminergic polymorphic ventricular tachycardia (CPVT) [39–41], arrhythmogenic right ventricular dysplasia type 2 [42–44] and sudden infant death syndrome [45].