Infection with a higher dose of H. capsulatum (5 × 106), Itgam-/-Clec7a-/- mice had significantly greater fungal burden, higher mortality and succumbed at an earlier time point (10 to14 days) compared to Itgam-/-, Clec7a-/- or WT mice (Fig 6D and 6E). Here, CLEC7A is linked to infection.