By contrast, the percentage and the number of neutrophils recruited to the spleen of Itgam-/- mice were commensurate with that in WT mice after intravenous inoculation of H. capsulatum. To focus on the roles of CR3 and Dectin-1 in macrophage interaction with H. capsulatum, we resorted to employ the disseminated histoplasmosis model by intravenous inoculation of the organism instead of pulmonary infection. The gene discussed is CRIPTO3; the disease is histoplasmosis.