While dendritic cells are major antigen-presenting cells and macrophage are the host, cytokine-producing cell and effector cell in infection by H. capsulatum, our study reveals that CR3 and Dectin-1 are of vital importance not only in their collaborative roles in macrophage cytokine production but also in instructing adaptive immune response against disseminated histoplasmosis. The gene discussed is CLEC7A; the disease is infection.