GCK and obesity due to melanocortin 4 receptor deficiency: We also reported new lead SNPs at 29 established glycaemic and obesity-related trait loci achieving genome-wide significance in our meta-analyses, of which 23 were not present in HapMap, and identified multiple distinct signals of association for WHRadjBMI at RSPO3 and for FG at GCK and G6PC2. Taken together, these novel loci, distinct association signals, and new lead SNPs have increased the trait variance explained for glycaemic and obesity-related traits, although the majority of the heritability remains unaccounted for.