LEP and obesity due to melanocortin 4 receptor deficiency: These 2 adipocytokines are closely related to obesity and/or resistance to insulin and are important in the development of metabolic syndrome (MetS) and its components.4–6 In this context, a positive correlation between serum uric acid (sUA) and Lep levels has also been reported,7–9 as well as negative correlation with AdipoQ.10,11