For examples, L-NAME animal model is dependent on the block of nitric oxide synthase [23, 24], which cannot reflect the complete spectrum of pathophysiological changes associated with hypertension in pregnancy; the mechanism undergoes the differences between the in vivo and in vitro experiments, whether some other peptides are also involved in the vascular remodeling induced by hypertension in pregnancy; ECs exist in the intima of vessel wall which are directly exposed to the circulating NPY, whether NPY also participates in EC dysfunction during hypertension in pregnancy. Here, NPY is linked to hypertensive disorder.