IL17A and neoplasm: In contrast to their earlier ascribed roles as short-lived effector cells, the memory characteristics of IL17-producing T cells have been unveiled and extensively studied as they have a propensity to persist in vivo while retaining significant cytolytic capacity as demonstrated in a number of tumor models.49, 50, 51 Thus, our data strongly suggest that GIFT7 imparts distinct signal transduction, gene transcription and cellular phenotype.