The reduction in repertoire diversity represents an important cause of weakened host immunity during aging.33 Indeed, thymic dysfunction can complicate numerous senescence-related immune pathologies; pharmacological regeneration of host immunity thus has a wide range of clinical applications.40 We investigated the utility of GIFT7-mediated T-cell regeneration by demonstrating the repopulation of resident thymic precursors increases the absolute numbers of viral-specific CD8+ T cells at day 7 post infection. This evidence concerns the gene CD8A and infection.