Of note, exogenous IL7 does not seem to promote GvHD in a conclusive manner, presumably because IL7-responsive subsets in the setting of lymphopenic recovery seem to reside in the effector memory/non-alloreactive compartment.56, 58 We therefore propose the use of GIFT7 or GIFT7-enhanced T-cell precursors for the treatment of human thymic hypoimmune ailments with unmet clinical needs. The gene discussed is IL7; the disease is graft versus host disease.