Silencing miR-100 led to a significant decrease in cell viability and a significant increase in caspase 3/7 activity in SK-BR-3 cells compared with controls (Non-treated and AMO-miR-100-scrambled) (Fig. 1C,D), indicating that miR-100 was involved in inhibiting apoptosis of breast cancer cells. This evidence concerns the gene CASP3 and breast carcinoma.