Misregulation of the ASPP proteins is tightly associated with the malignancy of the tumor and with poor prognosis of the patients1, 6, 7, 8, 9, 10, 11, 12.iASPP was identified as RelA-associated inhibitor (RAI), a 351 residues protein that binds and inhibits the transcriptional activity of the NFκB subunit p6513. The gene discussed is PPP1R13L; the disease is neoplasm.