ANO1 and neuropathic pain: In support of this idea, electrophysiological studies demonstrated that anoctamin-1 augments excitability and contributes to depolarization of dorsal root ganglia (DRG) neurons [19–21], while sciatic nerve axotomy enhances bestrophin-1 expression and calcium-activated chloride currents in DRG neurons [23, 28] suggesting the participation of CaCCs in neuropathic pain.