Genome-wide association study (GWAS) has revealed that the SLC22A3-LPAL2-LPA gene cluster was a risk locus for coronary artery disease, and the chromosomal region (6p26) where the SLC22A3-LPAL2-LPA gene cluster located is closely associated with the risk of CAD, and the LPA locus on 6q26-27 encoding lipoprotein has the strongest association [22]. Here, LPAL2 is linked to coronary artery disorder.