11. and Xu et al. 10. have previously shown by luciferase assay that miR-193b targets the CCND1 3’UTR in Malme-3M malignant melanoma and HepG2 hepatocellular carcinoma cells. In addition, we performed a rescue experiment, in which we cotransfected miR-193b into 22Rv1 cells with and without the pCMV-CCND1 plasmid lacking the 3’UTR of CCND1. These results show that CCND1 is a bona fide target of miR-193b in prostate cancer cells. This evidence concerns the gene CCND1 and hepatocellular carcinoma.