Disturbance of these networks can lead to malignant transformation, for example, RUNX1 and its binding partner CBFB control multiple aspects of normal haematopoiesis, but fusion proteins such as RUNX1-ETO or CBFB-MYH11 can cause acute myeloid leukaemia (AML).1, 2. Here, MYH11 is linked to acute myeloid leukemia.