Serum insulin levels were significantly decreased in the STZ-injected vehicle-treated group as compared to control vehicle-treated group both at week 4 (0.05 ± 0.01 vs. 0.16 ± 0.02 μg/mL) and 8 (0.08 ± 0.02 vs. 0.17 ± 0.02 μg/mL) proving deteriorated pancreatic beta cell function in DM. The gene discussed is INS; the disease is diabetes mellitus.