CCDC88C and cancer: Because Daple appears to be upregulated during cancer invasion and in circulating cancer cells (and such upregulation is associated with worse prognosis) and enhances non-canonical Wnt signaling downstream of FZD7R, it is possible that Daple's functional interaction with this receptor further enhances prometastatic signaling via amplification of the non-canonical Wnt pathway, which synergizes with the previously proposed forward-feedback canonical Wnt signaling loop during cancer progression.