When we analyzed Daple mRNA in another cohort of patients by quantitative PCR (qPCR), we confirmed that Daple is indeed downregulated in cancers (Figure 8B), but not in the precancerous advanced polyps (defined as any adenoma with >25% villous features, or ≥1.0 cm in size, or high-grade dysplasia); the latter showed a modest upregulation in Daple mRNA (Figure 8B). Here, CCDC88C is linked to adenoma.