This bimodal dysregulation (suppressed first, expressed later) and bi-faceted role (tumor suppressor in the normal epithelium, but enhancer of tumor invasion in cancer cells) during cancer progression mirrors what was previously unequivocally documented for the non-canonical Wnt5a signaling (McDonald and Silver, 2009)—Wnt5a signaling is suppressed earlier to allow cellular transformation and tumor growth, and enhanced later during tumor invasion. The gene discussed is WNT5A; the disease is cancer.