PTPN22 and type 1 diabetes mellitus: Fig 6 lists 19 networks of the interactions among three or more genes on individual chromosomes. For instance, the interactions among genes MAGI3 (rs1230658), PHTF1(rs1936398) and PTPN22 (rs1217410) on Chr 1 are evident, which is associated with Type 1 diabetes [41, 42]. Part of ZRANB3 gene (213 bp; rs6742030) on Chr 2 is antisense to spliced RAB3GAP1 gene (rs7422031; d = -0.0483±0.0075; r2d<0 = 0.6047±0.5590) according to the information from http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/. Many newly detected gene-gene interactions await experimental evidence (S3 Table).