Finally, our finding that Gal-8 treatment ameliorates EAU pathology has broad implications for developing novel therapeutic strategies not only for uveitis but also for a wide array of autoimmune diseases including multiple sclerosis, ulcerative colitis, and atherosclerosis, which are mediated by TH1 and TH17 cytokines and ameliorated by the action of Treg cells [41],[46],[47]. This evidence concerns the gene LGALS8 and ulcerative colitis.