Alternate pathways of activating Notch signalling, such as FBXW7 mutations (Gene ID: 55294) are seen in paediatric T-ALL [41], and tumours arising in Fbxw7+/- mice do not show Notch1 mutations or type 1 deletions [28] confirming the existence of redundant pathways for achieving tumour-permissive Notch signalling in both mice and humans. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.