A genome-wide linkage analysis and exome analysis recently identified ring finger protein 213 (RNF213) as the strongest susceptibility gene for MMD in East Asian people.[11] [12] Thus, we analyzed the occurrence of the p.Arg4810Lys variant of RNF213 in relation to angiographic findings in adult stroke patients with intracranial arterial stenosis. The gene discussed is RNF213; the disease is stroke disorder.