Interestingly, β-catenin protein level was higher in both CP10 and CP70 (Figure 3B), and this increased protein expression correlated with both CP10 and CP70 exhibiting >3-fold increase in TOP-eGFP Wnt reporter activity, as compared to their platinum-sensitive counterparts, showing that β-catenin-regulated transcriptional activity is increased in cisplatin-resistant ovarian tumor cells (Figure 3C). This evidence concerns the gene S100A8 and ovarian neoplasm.