Given that the iron chelators, DFO, Dp44mT and DpC, have been demonstrated to inhibit Src and c-Abl activity in certain cancer cell-types [121] and that they can markedly up-regulate NDRG1, it is plausible that these compounds could exhibit their anti-metastatic effects via NDRG1-mediated modulation of these pathways. This evidence concerns the gene NDRG1 and cancer.