Studies performed in PC3mm metastatic prostate and MCF7 breast cancer cells demonstrated that NDRG1 interacts with the Wnt receptor, LRP6, subsequently blocking the Wnt cascade to suppress the EMT and metastasis by reactivating GSK3β, promoting β-catenin degradation, and inhibiting downstream expression of ATF3 [107]. Here, NDRG1 is linked to breast carcinoma.