We found that the FAM83D protein was overexpressed in 69.44% (50/72) of the HCCs, but only 12.5% (9 of 72) of the non-HCC tissues stained positively for FAM83D, and the difference in FAM83D staining between the HCC and non-HCC tissues was statistically significant (P < 0.001). This evidence concerns the gene SACK1D and hepatocellular carcinoma.