SACK1D and neoplasm: The analysis revealed that a value of AFP ≥100 ng/ml (HR, 1.515; 95% CI, 1.063-2.160, P = 0.021), tumor size ≥5 cm (HR, 2.768; 95% CI, 1.550-4.943, P = 0.001), AST ≥40 U/l (HR, 1.780; 95% CI, 1.226-2.584, P = 0.002), and high FAM83D expression (HR, 1.568; 95% CI, 1.112-2.209, P = 0.010) were all independent predictors for the DFS (Table 3).