A value of AFP ≥100 ng/ml (HR, 1.770; 95% CI, 1.128-2.775, P = 0.013), tumor size ≥ 5 cm (HR, 2.622; 95% CI, 1.470-4.678, P = 0.001), AST ≥40 U/l (HR, 1.898; 95% CI, 1.304-2.762, P = 0.001), and high FAM83D expression (HR, 1.629; 95% CI, 1.138-2.333, P = 0.008) were also all independent predictors of the OS (Table 3). This evidence concerns the gene SACK1D and neoplasm.