Notably, our current findings indicated that the upregulation of FAM83D was not significantly correlated with gender, age (≥50 or <50 years old), tumor size (≥5 or <5 cm), family history, HBsAg expression, the size and the number of tumors, the presence of liver cirrhosis, alcohol consumption, distant metastasis or lymph node metastasis, postoperative recurrence, the level of AST, or the NLR (P > 0.05, Table 1). This evidence concerns the gene SACK1D and alcohol dependence.