The data obtained from the univariate analysis revealed that high FAM83D expression, AFP ≥100 ng/ml, a median size tumor ≥5 cm, multiple tumors, TMN stage III–IV, PVTT, distant metastasis or lymph node metastasis, AST ≥40 U/l and NLR ≥2.31 were all associated with a shorter DFS and OS. This evidence concerns the gene AFP and neoplasm.