INS and obesity due to melanocortin 4 receptor deficiency: Obesity is a state of glucose dysregulation, high levels of circulating insulin and reduced sensitivity to the metabolic actions of insulin, and some authors point that the higher BP values in obese individuals might result from persistent sympathetic overactivation and volume overload that are characteristic of IR, and that hyperinsulinemia might further increase sodium reabsorption, additionally contributing to additional volume overload independently of obesity [8].