INS and inborn error of immunity: The enrichment analysis of the KEGG signaling pathway for those DEGs found only in water buffalo showed that they are mainly involved in metabolic pathways, T cell receptor signaling pathways, histidine metabolism, vascular smooth muscle contraction, base excision repair, primary immunodeficiency, leukocyte transendothelial migration, natural killer cell-mediated cytotoxicity, the neurotrophin signaling pathway, the insulin signaling pathway, the Wnt signaling pathway, antigen processing and presentation (S9 Table).