FTO and major depressive disorder: The aim of this study was to assess whether BMI and MDD have an overlapping polygenic architecture using polygenic profile scores.15 This was explored in a large population-based cohort: Generation Scotland: the Scottish Family Health Study (GS:SFHS).16, 17 As MDD has been shown to moderate the effect of FTO variants on BMI, we hypothesized that the association between BMI polygenic profile scores and BMI would be moderated by the presence of MDD.