PTGS2 and chronic cystitis: Finally, in our model of rUTI, pretreatment of sensitized mice with the COX-2 specific inhibitor, SC-236, prior to high dose (108 cfu) UPEC challenge significantly decreased the incidence of recurrent chronic cystitis compared to treatment with vehicle or the COX-1 specific inhibitor SC-560 (Fig. 7A and B, 31% (8/26) vs. 77% (20/26) and 86% (6/7), respectively, P < 0.05 for each, Fisher's exact test).