Our observation that circulating miR10b is higher in ER negative disease was keeping with the findings of previous studies [11, 20, 24] which reported that miR10b was highly correlated to the ER or PR expression; great differences were detected in miR expression levels in samples that are hormone receptor negative, this was a predictive factor for prognosis in patients with breast cancer. This evidence concerns the gene NR4A1 and breast carcinoma.