DIM also inhibits pro-survival cell signaling pathways such as phosphatidylinositide 3-kinase (PI3K), Akt, mammalian target of rapamycin (mTOR) and c-Met, and also activates pro-apoptotic pathways such as Hippo and glycogen synthase kinase 3-beta (GSK-3β), resulting in inhibition of cancer cell proliferation [13-19]. This evidence concerns the gene GSK3B and cancer.