Moreover, salubrinal alone did not affect phosphorylation of eIF2α in all three cell lines (Fig. S2A, B), suggesting that, in prostate cancer cells, salubrinal does not directly modify the phosphorylation status of eIF2α; nor does it significantly inhibit the onset of ring-DIM-mediated ER stress. The gene discussed is EIF2A; the disease is prostate carcinoma.