However, in a variety of cases, CaMKII can be pro-apoptotic and in hepatocellular carcinoma cells CaMKII is necessary for melittin-induced apoptosis [13], and CaMKII activation has been linked to sustained c-Jun N-terminal kinase and p38 mitogen-activated kinase stress signaling [13, 45, 46]. The gene discussed is CAMK2G; the disease is hepatocellular carcinoma.