To confirm the overexpression of GADD45α protein through the combination of our gene therapy vector and resveratrol treatment delays lung cancer progression and increases cancer cell apoptosis, we transfected A549 cells with pT.Luc (control vector), pE9NS.G45α or pE460.G45α for 24 h and then treated with either 0.1% DMSO or 100 μM of resveratrol for additional 24 h before proceeding to western blotting, MTT assay and Annexin-V/propidium iodide (PI) flow cytometric analysis. The gene discussed is GADD45A; the disease is cancer.