Although GADD45α fails to arrest cell cycle progression at G2/M checkpoint in p53-deficient cancer cells, it is still able to suppress cell proliferation via inducing apoptosis [43], indicating that GADD45α-mediated G2/M arrest depends on normal p53 function whereas GADD45α-induced apoptosis is irrelevant to p53. The gene discussed is GADD45A; the disease is cancer.