CCL2 expression on the surface of glioma cells which attracts macrophages to the tumor site, with its ensuing activation of other components of immune system through secretion of humoral factors on one end and eradication of inflammation without any observable effect on tumor growth and progression on the other end, are among the examples that take away the designation of driver role from chronic inflammation in inflammation associated malignancies. This evidence concerns the gene CCL2 and glioma.