Finally some of the famous misunderstood drivers of malignant path such as RAS in adenocarcinoma of pancreas, HER family in breast cancer, EGFR in lung cancer and gliomas, all have one thing in common, namely increasing the pace of mitosis of low free energy cancer cells, a futile attempt at increasing the free energy of cancer cells which could potentially lead to inflammatory response in the tumor microenvironment and promote debilitating cancer associated symptomatologies such as fatigue and weight loss. This evidence concerns the gene EGFR and cancer.