Mice with simultaneous Treg-specific deletion of p300 and CBP develop severe autoimmunity, as both p300 and CBP interact not only with FOXP3, but also with many FOXP3-regulating TFs including NFAT, STAT1, FOXO1, FOXO3, NF-κB, RUNX1, and STAT5 [72, 74-78]. The gene discussed is FOXP3; the disease is Autoimmunity.