INS and polycystic ovary syndrome: Although few studies exist focusing on high molecular weight adiponectin and the earlier meta-analysis did not specifically evaluate levels of high molecular weight (HMW) adiponectin [98], which is considered to be a more potent mediator of insulin sensitivity [100], it has been reported that levels of HMW adiponectin and the ratio of HMW adiponectin to total adiponectin are both lower in PCOS women than in age- and BMI-comparable controls [101].