The increase in CIMT in PCOS relative to controls of comparable age and BMI has been associated in different studies with higher levels of insulin [57], hyperandrogenism [156], Il-18 [157], LDL-C [157], and abdominal obesity [157], although the contribution of each of these factors to increased CIMT in PCOS has not been systematically evaluated [157]. The gene discussed is INS; the disease is polycystic ovary syndrome.