MIF and Impaired glucose tolerance: Yu et al. (48) showed that plasma MIF levels were higher in a pre-diabetic rat model of impaired glucose tolerance (HFD-fed and STZ- and L-NAME-treated Sprague-Dawley rats) than in chow-fed controls (32.5 ± 1.9 vs. 24.8 ± 1.6 ng/ml).