Furthermore, they showed that in wild-type pancreatic islets, palmitic acid (a saturated fatty acid which is present in human diets as well as in experimental HFDs) induces MIF production and apoptosis, while pancreatic islets from Mif-deficient mice were entirely resistant to palmitic acid-induced apoptosis, which may be of importance in β-cell apoptosis in late-stage obesity-associated T2D. This evidence concerns the gene MIF and obesity due to melanocortin 4 receptor deficiency.