First, clinical syndromes are diverse and different regions and networks in the CNS seem to be afflicted, e.g., the hippocampus and amygdala in the subgroup of anti-GAD65 aAB positive limbic encephalitis, the brainstem and spinal cord in SPS, or the cerebellum in cerebellar ataxia (5). This evidence concerns the gene GAD2 and cerebellar ataxia.