TNFAIP3 and glioblastoma: A20 was found to be largely overexpressed in human glioblastoma stem cells (GSCs) and glioma tissue samples (Guo et al., 2009; Hjelmeland et al., 2010) and siRNA-mediated downregulation of A20 in U87 glioblastoma cells as well as in a mouse Xenograft tumor model led to significantly reduced tumor growth and tumor size (Guo et al., 2009).