SNPs in the TNFAIP3 gene, but also in other immune-regulatory genes including HLA-C, TNIP1/ABIN-1 and IL-23A (Nair et al., 2009; Strange et al., 2010; Johnson-Huang et al., 2012) have been associated to psoriasis and polymorphisms in the TNFAIP3 gene correlate to responsiveness to TNFα blockers in psoriasis patients (Tejasvi et al., 2012). This evidence concerns the gene HLA-C and psoriasis.