TNFAIP3 and autoimmune disease: In humans, single nucleotide polymorphisms (SNPs) of the TNFAIP3 gene have been associated with a range of autoimmune diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease, psoriasis and type one diabetes (Musone et al., 2011; Ma and Malynn, 2012).