Furthermore, reduced nuclear localization of the Rel-A (p65) subunit of the NFκB dimer confers protection in the study mentioned above, while a deficiency in the c-Rel subunit of NFκB renders mice to develop parkinsonism with aging, characterized by microglia, but not astrocyte, activation (Baiguera et al., 2012). The gene discussed is NFKB1; the disease is Parkinsonism.