Mice lacking A20 specifically in CD11c+ dendritic cells show phenotypical similarities to human SLE including glomerulonephritis, presence of antibodies against dsDNA, ribonucleoprotein and cardiolipin, thrombocytopenia and autoimmune lymphoproliferative syndrome (ALPS) including enhanced spontaneous lymphocyte activation, accumulation of double negative lymphocytes and myeloproliferative syndrome (Kool et al., 2011). This evidence concerns the gene TNFAIP3 and systemic lupus erythematosus.