In addition, signaling via NF-κB transcription factors is altered in age-related diseases including neurodegenerative diseases, diabetes and atherosclerosis (Verma, 2004; Chami et al., 2012; Müller-Rischart et al., 2013; Pranski et al., 2013; Woodling et al., 2014; Zhang et al., 2014). Here, NFKB1 is linked to neurodegenerative disease.