These initial findings, together with the fact that Cezanne 1 regulates nuclear localization of DJ-1/Parkin 7, mutated forms of which are associated with the early-onset form of PD (McNally et al., 2011; Saito et al., 2014), may suggest potential roles for Cezanne proteins in the regulation of NF-κB activity in inflammatory responses to ischemia, and in neurodegenerative diseases. The gene discussed is NFKB1; the disease is neurodegenerative disease.