Two other A20 related deubiquitinating cysteine proteases Cezanne 1 (Cellular zinc finger anti- NF-κB Otud7b/Ovarian tumor domain) and Cezanne 2 (Otud7a) were identified on the basis of their overall sequence similarity to A20 and due to their potential to regulate NF-κB signaling and were hence termed to belong to “A20 family of proteins” (Evans et al., 2001; Enesa et al., 2008). Here, TNFAIP3 is linked to ovarian neoplasm.