We also noticed that Doxo treatment led to significantly induced Caspase 3/7 activities in SMMC-7721 and Bel-7402 cells, but not in HL-7702 cells (Figure 1C), suggesting that Doxo can only induce apoptosis in HCC cells but not in normal hepatocytes. The gene discussed is CASP3; the disease is hepatocellular carcinoma.