To simulate the HCC-like, increased p-AKT levels in hepatocyte, we consequently overexpressed exogenous AKT-Myc and Madcam1-Myc in HL-7702 cells, and noticed a gradual up-regulation of the p-AKT levels (Figure 7B-7C). The gene discussed is MADCAM1; the disease is hepatocellular carcinoma.