Further sub-analyses of the expression of the ghrelin components according to tumor site (primary or metastatic tissues) showed a consistent increase of In1-ghrelin as well as of the two ghrelin receptors (GHSR1a and GHSR1b) in both categories, while GOAT and native ghrelin expression levels were elevated only in metastatic tissues (Supplemental Figure 1). This evidence concerns the gene GHRL and neoplasm.