Dokic et al. also demonstrated that glioma cell lines exhibited a deficiency in GPx1 expression and activity, which led to an accumulation of reactive oxygen/nitrogen species (ROS/RNS) and subsequent death of cells after induction of oxidative stress, while astrocytes and glioma stem cell lines expressed active GPx1 and resisted ROS/RNS-mediated cell death [21], which was consistent with our results. This evidence concerns the gene GPX1 and central nervous system cancer.