TP53 and lip and oral cavity carcinoma: The result showed that the association of HPV with p53 Arg72Pro variant genotypes displayed a statistical significance on oral cancer risk in the Arg/Arg vs. Pro carriers (Arg/Pro + Pro/Pro) model (OR: 0.68, 95 % CI: 0.48- 0.96, p = 0.028) (Fig. 2, Table 3).