The presence in the AE clade consensus of the very residues that are selected in B or C clade infected subjects as escape mutants in two of the four HLA-27:05/B*57:01-restricted p24 Gag-specific epitopes, ISPRTLNAW (Gag 147-155, ‘ISW9’) and KAFSPEVIPMF (Gag 162-172, ‘KF11’), prompted the question of whether well-defined HLA-B*27:05/57:01-restricted epitopes are accessible in AE clade infection. Here, HLA-B is linked to infection.