In radiation-treated cancer cells, LIN28A/LIN28B over-expression reportedly inhibits the expression of gamma-H2AX, which is an activate form of histone H2AX and is necessary for repair of double strand breaks (DSBs) [98], which suggests that LIN28A/LIN28B may increase genome instability by inhibiting DSB repair [85]. The gene discussed is LIN28B; the disease is cancer.