The data from Pello et al. demonstrated that the activation of tumor-associated macrophage requires the transcription factor c-MYC, and c-MYC controls the induction of about 45 % of genes associated with M2 macrophage activation, such as SCARB1, ALOX15 and MRC1; whereas myc inhibition prevents the activation of M2 macrophages and their pro-tumorigenic behavior [105]. This evidence concerns the gene MYC and neoplasm.